Crizalk 250mg Capsule - Crizotinib Uses & Side effects

CRIZALK 250MG




DESCRIPTION


Crizalk 250mg capsule belongs to type of tyrosine kinase inhibitor. Kinases are enzymes which are contain in many functions, including cell development and reproduction.

Crizalk 250mg prohibit the anaplastic lymphoma kinase (ALK) and the c-MET/hepatocyte growth factor receptor. This activity depresses certain pathways in the cell, which can prevent the growth of tumor cells.


PRODUCT DETAILS


Trade name                             Crizalk 
Active component                  Crizotinib 
Strength                                  250mg 
Manufactured by                    Pfizer Ltd 
Form                                      Capsules 
Packing                                  60 tablets


MECHANISM OF ACTION



  • More specifically, crizotinibprevents anaplastic lymphoma kinase (ALK), hepatocyte growth factor receptor (HGFR, c-MET), and Recepteurd'OrigineNantais (RON). 
  • Malformationin the ALK gene result by mutations or alteration may causes expression of oncogenic fusion proteins. Certain patients with NSCLC, they have the EML4-ALK gene. 
  • Crizotinib inhibits ALK tyrosine kinase which normally results in reducedmultiplication of cells which carry the genetic mutation and tumour survivability.



PREGNANCY


  • Based on studies of animal and mechanism of action, Crizalk 250mg will cause fetal harm when given to pregnant women. 
  • Advice the female not to become pregnant while on treatment with Crizalk 250mg


SIDE EFFECTS


• Bowel changes
• Feeling sick
• Swelling of hands and feet’s
• Decreased appetite
• Fatigue
• Liver changes
• Skin rash
• bradycardia
• Infection increased
• Breathlessness
• Eyesight changes.


MISSED DOSE


If the patient vomits after taking a dose of Crizalk 250mg or missed to take a dose, then should not to take an extra dose, but to take the next dose at the regular time, skip the missed dose.


STORAGE


Store the drug at 200C to 250C.



PRESCRIPTION

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