Crizalk 200mg Capsule - Crizotinib Uses & Side effects

CRIZALK 200MG




DESCRIPTION


Crizalk 200mg capsule belongs to type of tyrosine kinase inhibitor. Kinases are enzymes which are contain in many functions, including cell development and reproduction.

Crizalk 200mg prohibit the anaplastic lymphoma kinase (ALK) and the c-MET/hepatocyte growth factor receptor. This activitydepresses certain pathways in the cell, which can prevent the growth of tumor cells.


PRODUCT DETAILS


Trade name                  Crizalk 
Active component       Crizotinib 
Strength                       200mg 
Manufactured by         Pfizer Ltd 
Form                            Capsules 
Packing                        60 tablets


MECHANISM OF ACTION



  • More specifically, crizotinibprevents anaplastic lymphoma kinase (ALK), hepatocyte growth factor receptor (HGFR, c-MET), and Recepteurd'OrigineNantais (RON). 
  • Malformationin the ALK gene result by mutations or alteration may causes expression of oncogenic fusion proteins. Certain patients with NSCLC, they have the EML4-ALK gene. 
  • Crizotinib inhibits ALK tyrosine kinase which normally results in reducedmultiplication of cells which carry the genetic mutation and tumour survivability.



PREGNANCY


  • Based on studies of animal and mechanism of action, Crizalk 200mg will cause fetal harm when given to pregnant women. 
  • Advice the female not to become pregnant while on treatment with Crizalk 200mg.


SIDE EFFECTS


• Bowel changes
• Feeling sick
• Swelling of hands and feet’s
• Decreased appetite
• Fatigue
• Liver changes
• Skin rash
• Bradycardia
• Infection increased
• Breathlessness
• Eyesight changes


STORAGE


Store the drug at 200C to 250C.



PRESCRIPTION

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